BCRgt: a Bayesian cluster regression-based genotyping algorithm for the samples with copy number alterations
نویسندگان
چکیده
منابع مشابه
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays.
We have developed a robust algorithm for copy number analysis of the human genome using high-density oligonucleotide microarrays containing 116,204 single-nucleotide polymorphisms. The advantages of this algorithm include the improvement of signal-to-noise (S/N) ratios and the use of an optimized reference. The raw S/N ratios were improved by accounting for the length and GC content of the PCR ...
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15 صفحه اولScreening and merging algorithm for the detection of copy-number alterations
We call change-point problem (CPP) the identification of changes in the probabilistic behavior of a sequence of observations. Solving the CPP involves detecting the number and position of such changes. In genetics the study of how and what characteristics of a individual’s genetic content might contribute to the occurrence and evolution of cancer has fundamental importance in the diagnosis and ...
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Abnormal genome copy number alterations (CNAs) are associated with many severe diseases. Advances in microarray technology have greatly improved the resolution of detection of DNA copy number changes. This poses a challenge to existing computational methods to process the data accurately and efficiently. We compare two approaches to CNA detection for speed and accuracy. The first is a modified ...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2014
ISSN: 1471-2105
DOI: 10.1186/1471-2105-15-74